Summary:

This article will help you to change the components to 64-bits for a MSI project in InstallShield using IDE as well as automation script. 

Discussion:

1) Through InstallShield IDE follow the below Steps. You can do this if you have few components to be updated.
*) In the Installation Designer, select the Components under Organization and change the '64-Bit Component' to YES.

*) Since we use 64x bit component, make sure in the Template Summary under General information is set to 'intel;1033'. 

2) Through automation, Kindly execute the attached script '64bit component.vbs' if you have more components that needs to be changed.

*) You have to modify the script and mention the "<Path to ISM File>" in the Vbs script.

*) Note - If you are using InstallShield 2019, then you are good to execute the script as it is (You can modify it based on the requirement).
If you are using InstallShield 2020, then comment 'ISWiAuto25.ISWiProject' line and uncomment the 'ISWiAuto26.ISWiProject' line.

*) '64bit component.vbs' needs to be executed as in the path highlighted below (for reference),