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  • To compress the InstallShield prerequisites into the Setup.exe file and have them extracted at run time if they need to be launched on a target system: In the Releases view, select the release that you are configuring. On the Setup.exe tab, in the InstallShield Prerequisites Location setting, select Extract from Setup.exe.

     

    The next time that you build the release, InstallShield compresses the prerequisite files into your Setup.exe file.

     

    I hope that helps.
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How to package Prerequisites into the Single Image Exe